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Risk of venous thromboembolism after new onset heart failure

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Yayıncı Sürümü - Makale (925.0Kb)

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info:eu-repo/semantics/openAccess

Date

2019

Author

Smilowitz, Nathaniel R.
Zhao, Qi
Wang, Li
Shrestha, Sulena
Başer, Onur
Berger, Jeffrey S.

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Citation

Smilowitz, N. R., Zhao, Q., Wang, L., Shrestha, S., Baser, O., & Berger, J. S. (December 01, 2019). Risk of Venous Thromboembolism after New Onset Heart Failure. Scientific Reports, 9, 1, 1-6. DOI: 10.1038/s41598-019-53641-0

Abstract

New-onset heart failure (HF) is associated with cardiovascular morbidity and mortality. It is uncertain to what extent HF confers an increased risk of venous thromboembolism (VTE). Adults >= 65 years old hospitalized with a new diagnosis of HF were identified from Medicare claims from 2007-2013. We identified the incidence, predictors and outcomes of VTE in HF. We compared VTE incidence during follow-up after HF hospitalization with a corresponding period 1-year prior to the HF diagnosis. Among 207,535 patients with a new HF diagnosis, the cumulative incidence of VTE was 1.4%, 2.5%, and 10.5% at 30 days, 1 year, and 5 years, respectively. The odds of VTE were greatest immediately after newonset HF and steadily declined over time (OR 2.2 [95% CI 2.0-2.3], OR 1.5 [1.4-1.7], and OR 1.2 [1.2-1.3] at 0-30 days, 4-6 months, and 7-9 months, respectively). Over 26-month follow-up, patients with HF were at two-fold higher risk of VTE than patients without HF (adjusted HR 2.31 [2.18-2.45]). VTE during follow-up was associated with long-term mortality (adjusted HR 1.60, 95% CI 1.56-1.64). In conclusion, patients with HF are at increased risk of VTE early after a new HF diagnosis. VTE in patients with HF is associated with long-term mortality.

Source

Scientific Reports

Volume

9

Issue

1

URI

https://doi.org/10.1038/s41598-019-53641-0
https://hdl.handle.net/20.500.11779/1250

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  • Araştırma Çıktıları, PubMed Koleksiyonu [70]
  • Araştırma Çıktıları, Scopus İndeksli Yayınlar Koleksiyonu [429]
  • Araştırma Çıktıları, WOS İndeksli Yayınlar Koleksiyonu [470]
  • İİSBF, EB, Makale Koleksiyonu [61]



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