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dc.contributor.authorSchuler, Charles F
dc.contributor.authorVolertas, Sofija
dc.contributor.authorKhokhar, Dilawar
dc.contributor.authorYüce, Huseyin
dc.contributor.authorChen, Lu
dc.contributor.authorBaşer, Onur
dc.contributor.authorMontejo, Jenny M
dc.contributor.authorAkın, Cem
dc.date.accessioned2021-04-26T18:36:05Z
dc.date.available2021-04-26T18:36:05Z
dc.date.issued2021en_US
dc.identifier.citationSchuler, C. F., Volertas, S., Khokhar, D., Yuce, H., Chen, L., Baser, O., … Akin, C. (22 April 2021). Prevalence of mastocytosis and hymenoptera venom allergy in the United States. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2021.04.013en_US
dc.identifier.urihttps://doi.org/10.1016/j.jaci.2021.04.013
dc.identifier.urihttps://hdl.handle.net/20.500.11779/1484
dc.description.abstractBackground : Mastocytosis is a risk factor for hymenoptera venom anaphylaxis (HVA). Current guidelines recommend measuring tryptase in HVA patients and that those with mastocytosis pursue lifelong venom immunotherapy (VIT). Available data on HVA and mastocytosis largely derives from European single-center studies and the prevalence of HVA with and without mastocytosis in the United States (US) is unknown. Objective : We sought to determine the prevalence of HVA and mastocytosis in the US using an insurance claims database and evaluate the impact of mastocytosis on VIT in HVA patients in a US cohort. Methods :The IBM Watson Database, consisting of insurance claims from approximately 27 million US patients in 2018, was queried to identify patients with HVA and/or mastocytosis. Further, a retrospective study of 161 patients undergoing VIT between 2015 – 2018 at the University of Michigan (U-M) was conducted. Results :In the IBM Watson Database, the prevalence of HVA was 167 per 100,000 (0.167%) and the prevalence of mastocytosis 10 per 100,000 (0.010%) overall and 97 per 100,000 (0.097%) among those with HVA. Mastocytosis showed a 9.7-fold increase among HVA patients versus the general population. In the U-M cohort, 2.6% of VIT patients had mastocytosis. Tryptase level did not correlate with venom reaction severity but was higher in patients with systemic VIT reactions. Conclusions :We observed a lower US HVA prevalence than previously reported. Mastocytosis was more common in US HVA patients, though at lower rates than previously reported. In VIT patients there was no correlation between tryptase level and reaction severity. Key words :Tryptasevenom allergyvenom immunotherapyanaphylaxismastocytosismast cell activation syndromemast cell disease Abbreviations Hymenoptera venom allergyHVAUnited StatesUSVenom immunotherapyVITMast Cell DiseaseMCDAmerican Academy of Allergy, Asthma, and Immunologyen_US
dc.language.isoengen_US
dc.relation.ispartofJournal of Allergy and Clinical Immunology.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTryptase; anaphylaxisen_US
dc.subjectMast cell activation syndromeen_US
dc.subjectMast cell diseaseen_US
dc.subjectMastocytosisen_US
dc.subjectVenom allergyen_US
dc.subjectVenom immunotherapyen_US
dc.titlePrevalence of mastocytosis and hymenoptera venom allergy in the United Statesen_US
dc.typearticleen_US
dc.departmentİİSBF, Ekonomi Bölümüen_US
dc.authoridOnur Başer / 0000-0003-3328-0072en_US
dc.identifier.startpage1-31en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wosidWOS:000717466600002en_US
dc.description.scopusid2-s2.0-85106369702en_US
dc.contributor.institutionauthorBaşer, Onur
dc.description.pubmedid33895259en_US
dc.description.woscitationindexScience Citation Index Expandeden_US
dc.identifier.wosqualityQ1en_US
dc.description.WoSDocumentTypeArticleen_US
dc.description.WoSInternationalCollaborationUluslararası işbirliği ile yapılan - EVETen_US
dc.description.WoSPublishedMonthKasımen_US
dc.description.WoSIndexDate2021en_US
dc.description.WoSYOKperiodYÖK - 2021-22en_US
dc.identifier.doi10.1016/j.jaci.2021.04.013en_US
dc.identifier.scopusqualityQ1en_US


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