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Patterns of international normalized ratio values among new warfarin patients with nonvalvular atrial fibrillation

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info:eu-repo/semantics/closedAccess

Date

2016

Author

Nelson, Winnie W.
Milentijevic, Dejan
Wang, Li
Başer, Onur
Damaraju, Chandrasekharrao, V
Schein, Jeffrey R

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Citation

Nelson, W. W., Milentijevic, D., Wang, L., Baser, O., Damaraju, C. V., & Schein, J. R., (2016). Patterns of international normalized ratio values among new warfarin patients with nonvalvular atrial fibrillation. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 27, 8, 899-906.

Abstract

Limited information exists regarding the relationship between international normalized ratio (INR) control/stability and the discontinuation of warfarin therapy among patients with nonvalvular atrial fibrillation (NVAF). This study evaluated the association between INR stabilization and warfarin discontinuation and assessed INR patterns before and after INR stabilization among patients (18 years) with NVAF who newly initiated warfarin (Veterans Health Administration datasets; October 1, 2007 through September 30, 2012). Achievement of INR stabilization (3 consecutive in-range therapeutic INR measurements 7 days apart) was examined from warfarin initiation through the end of warfarin exposure. Proportion of time in therapeutic range during warfarin exposure was calculated (Rosendaal method) and categorized as at least 60% or less than 60%. Among 34346 patients, 49.4% achieved INR stabilization (mean time to stabilization, 98 days). Approximately 40% of INR values were out-of-range, even after achieving stabilization. During 30 days following an INR 4.0 or higher, patients had more INR testing than the overall mean (2.51 vs. 1.67 tests). Warfarin discontinuation was 4.2 times more likely among patients without INR stabilization versus those with INR stabilization (P<0.00001). Patients with poor INR control (time in therapeutic range <60%) were 1.76 times more likely to discontinue warfarin within 1 year (P<0.0001). INR stabilization is a better predictor of warfarin discontinuation than poor INR control. Improved approaches are necessary to maintain appropriate anticoagulation levels among patients with NVAF.

Source

Blood Coagulation & Fibrinolysis

Volume

27

Issue

8

URI

http://dx.doi.org/10.1097/MBC.0000000000000515
https://hdl.handle.net/20.500.11779/668

Collections

  • Araştırma Çıktıları, PubMed Koleksiyonu [70]
  • Araştırma Çıktıları, Scopus İndeksli Yayınlar Koleksiyonu [429]
  • Araştırma Çıktıları, WOS İndeksli Yayınlar Koleksiyonu [470]
  • İİSBF, EB, Makale Koleksiyonu [61]



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