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dc.contributor.authorNelson, Winnie W.
dc.contributor.authorMilentijevic, Dejan
dc.contributor.authorWang, Li
dc.contributor.authorBaşer, Onur
dc.contributor.authorDamaraju, Chandrasekharrao, V
dc.contributor.authorSchein, Jeffrey R
dc.date.accessioned2019-02-28T13:04:26Z
dc.date.accessioned2019-02-28T11:08:17Z
dc.date.available2019-02-28T13:04:26Z
dc.date.available2019-02-28T11:08:17Z
dc.date.issued2016en_US
dc.identifier.citationNelson, W. W., Milentijevic, D., Wang, L., Baser, O., Damaraju, C. V., & Schein, J. R., (2016). Patterns of international normalized ratio values among new warfarin patients with nonvalvular atrial fibrillation. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 27, 8, 899-906.en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.urihttp://dx.doi.org/10.1097/MBC.0000000000000515
dc.identifier.urihttps://hdl.handle.net/20.500.11779/668
dc.descriptionOnur Başer (MEF Author)en_US
dc.description.abstractLimited information exists regarding the relationship between international normalized ratio (INR) control/stability and the discontinuation of warfarin therapy among patients with nonvalvular atrial fibrillation (NVAF). This study evaluated the association between INR stabilization and warfarin discontinuation and assessed INR patterns before and after INR stabilization among patients (18 years) with NVAF who newly initiated warfarin (Veterans Health Administration datasets; October 1, 2007 through September 30, 2012). Achievement of INR stabilization (3 consecutive in-range therapeutic INR measurements 7 days apart) was examined from warfarin initiation through the end of warfarin exposure. Proportion of time in therapeutic range during warfarin exposure was calculated (Rosendaal method) and categorized as at least 60% or less than 60%. Among 34346 patients, 49.4% achieved INR stabilization (mean time to stabilization, 98 days). Approximately 40% of INR values were out-of-range, even after achieving stabilization. During 30 days following an INR 4.0 or higher, patients had more INR testing than the overall mean (2.51 vs. 1.67 tests). Warfarin discontinuation was 4.2 times more likely among patients without INR stabilization versus those with INR stabilization (P<0.00001). Patients with poor INR control (time in therapeutic range <60%) were 1.76 times more likely to discontinue warfarin within 1 year (P<0.0001). INR stabilization is a better predictor of warfarin discontinuation than poor INR control. Improved approaches are necessary to maintain appropriate anticoagulation levels among patients with NVAF.en_US
dc.language.isoengen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiscontinuationen_US
dc.subjectInstabilityen_US
dc.subjectInternational normalized ratioen_US
dc.subjectOut-of-rangeen_US
dc.subjectWarfarinen_US
dc.titlePatterns of international normalized ratio values among new warfarin patients with nonvalvular atrial fibrillationen_US
dc.typearticleen_US
dc.departmentİİSBF, Ekonomi Bölümüen_US
dc.identifier.volume27en_US
dc.identifier.issue8en_US
dc.identifier.startpage899en_US
dc.identifier.endpage906en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wosidWOS:000387268500009en_US
dc.description.scopusid2-s2.0-84958818195en_US
dc.contributor.institutionauthorBaşer, Onur
dc.description.pubmedidPMID: 26886362en_US
dc.description.woscitationindexScience Citation Index Expandeden_US
dc.description.qualityQ4en_US
dc.description.WoSDocumentTypeArticleen_US
dc.description.WoSInternationalCollaborationUluslararası işbirliği ile yapılan - EVETen_US
dc.description.WoSPublishedMonthAralıken_US
dc.description.WoSIndexDate2016en_US
dc.description.WoSYOKperiodYÖK - 2016-17en_US
dc.identifier.doi10.1097/MBC.0000000000000515en_US


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